Xu Yong, Gu Xuejun, Fajardo Laurie L, Jiang Huabei
Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, USA.
Appl Opt. 2003 Jun 1;42(16):3163-9. doi: 10.1364/ao.42.003163.
We report on in vivo absorption and scattering imaging of a human breast cyst and implant, using a reconstruction algorithm based on our third-order diffusion equations. To validate these in vivo images, a series of phantom experiments were conducted, in which we used low-absorbing and low-scattering heterogeneities to mimic a breast cyst or implant. These heterogeneities or targets were composed of pure water or a mixture of water and very dilute Intralipid (0.05% and 0.1%). The phantom experiment confirmed the quantitative imaging capability of our improved algorithm for reconstructing heterogeneities where the conventional diffusion approximation is inadequate. Pilot clinical results from female volunteers indicate that enhanced diffuse optical tomography can quantitatively image findings such as breast cysts or implants in which the absorption and scattering coefficients are usually low.
我们报告了使用基于三阶扩散方程的重建算法对人乳腺囊肿和植入物进行的体内吸收和散射成像。为了验证这些体内图像，我们进行了一系列体模实验，其中使用低吸收和低散射不均匀性来模拟乳腺囊肿或植入物。这些不均匀性或目标由纯水或水与极稀的脂质乳剂（0.05%和0.1%）的混合物组成。体模实验证实了我们改进算法在传统扩散近似不适用时重建不均匀性的定量成像能力。女性志愿者的初步临床结果表明，增强型扩散光学断层扫描可以对诸如乳腺囊肿或植入物等吸收和散射系数通常较低的情况进行定量成像。
