Sharma Anil K, Hergenrother Paul J
Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Org Lett. 2003 Jun 12;5(12):2107-9. doi: 10.1021/ol0345327.
[reaction: see text] A variety of beta-amino-gamma-keto acids were prepared in four steps from commercially available l-homoserine. The reaction sequence is highlighted by a Ni-catalyzed Grignard addition to a N-protected derivative of l-homoserine. One of the beta-amino-gamma-keto acids was then used to create a beta-peptide trimer composed solely of beta-amino-gamma-keto acids.
