Synthesis of louisianin C.
作者信息
Beierle John M, Osimboni Ekundayo B, Metallinos Costa, Zhao Yajun, Kelly T Ross
机构信息
Department of Chemistry, Eugene F. Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
出版信息
J Org Chem. 2003 Jun 13;68(12):4970-2. doi: 10.1021/jo0341618.
PMID:12790613
Abstract
The synthesis of louisianin C (3), a member of a small family of 3,4,5-trisubstituted pyridyl natural products, is achieved in six steps and 11% overall yield starting from commercially available 3,5-dibromopyridine. The key step is a fluoride-induced desilylation-cyclization to afford carbinol 12.
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