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通过Ti(O-i-Pr)(4)/2 i-PrMgCl介导的金属化瑞佩反应合成光学活性茚满-2-醇的高效实用方法。

Efficient and practical method for synthesizing optically active indan-2-ols by the Ti(O-i-Pr)(4)/2 i-PrMgCl-mediated metalative Reppe reaction.

作者信息

Hanazawa Takeshi, Sasaki Kousuke, Takayama Yuuki, Sato Fumie

机构信息

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

出版信息

J Org Chem. 2003 Jun 13;68(12):4980-3. doi: 10.1021/jo034391m.

DOI:10.1021/jo034391m
PMID:12790616
Abstract

An efficient and practical synthesis of optically active indan-2-ols 1 has been developed starting from readily accessible optically active 4-siloxy-1,6-alkadiynes 2 and ethynyl p-tolyl sulfone, where the metalative Reppe reaction mediated by an economical divalent titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, is a key step.

摘要

已开发出一种高效实用的方法，从易于获得的旋光性4-硅氧基-1,6-二炔2和乙炔基对甲苯砜出发合成旋光茚满-2-醇1，其中由经济的二价钛试剂Ti(O-i-Pr)(4)/2 i-PrMgCl介导的金属化瑞佩反应是关键步骤。

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