促性腺激素释放激素（GnRH）-I和GnRH-II在卵巢及卵巢癌中的潜在作用。

Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer.

作者信息

Kang S K, Choi K-C, Yang H-S, Leung P C K

机构信息

Department of Obstetrics and Gynaecology, University of British Columbia, 2H-30, 4490 Oak Street, Vancouver, BC V6H 3V5, Canada.

出版信息

Endocr Relat Cancer. 2003 Jun;10(2):169-77. doi: 10.1677/erc.0.0100169.

DOI:10.1677/erc.0.0100169

PMID:12790779

Abstract

Gonadotrophin-releasing hormone (GnRH) functions as a key neuroendocrine regulator of the hypothalamic-pituitary-gonadal axis. In addition to the hypothalamus and pituitary gland, GnRH and its receptor have been detected in other reproductive tissues including the gonads, placenta and tumours arising from these tissues. Recently, a second form of GnRH (GnRH-II) and type II GnRH receptor have been found in normal ovarian surface epithelium and neoplastic counterparts. The two types of GnRH may play an important role as an autocrine/paracrine regulator of reproductive functions and ovarian tumour growth. In this review, the distribution and potential roles of GnRH-I/-II and their GnRH receptors in the ovarian cells and ovarian cancer will be discussed.

摘要

促性腺激素释放激素（GnRH）是下丘脑-垂体-性腺轴的关键神经内分泌调节因子。除下丘脑和垂体外，在包括性腺、胎盘以及源自这些组织的肿瘤在内的其他生殖组织中也检测到了GnRH及其受体。最近，在正常卵巢表面上皮及其肿瘤对应物中发现了第二种形式的GnRH（GnRH-II）和II型GnRH受体。这两种类型的GnRH可能作为生殖功能和卵巢肿瘤生长的自分泌/旁分泌调节因子发挥重要作用。在本综述中，将讨论GnRH-I/-II及其GnRH受体在卵巢细胞和卵巢癌中的分布及潜在作用。