不同氨基酸的N-乙酰乙酯从有机溶剂转移至水中的热力学参数。

Thermodynamic parameters of transfer of N-acetyl ethyl esters of different amino acids from organic solvents to water.

作者信息

Nandi P K

出版信息

Int J Pept Protein Res. 1976;8(3):253-64. doi: 10.1111/j.1399-3011.1976.tb02501.x.

DOI:10.1111/j.1399-3011.1976.tb02501.x

Abstract

The distribution coefficients of N-acetyl ethyl esters of glycine, diglycine, beta-alanine, alanine, valine, norvaline, leucine and norleucine between water and different organic solvents have been measured at different temperatures. Similar distribution coefficients have been measured for simple amides, urea, formamide, acetamide and N-methyl acetamide. From the distribution measurements, deltaGtr, the free energy of transfer of the solutes from organic solvents to water has been calculated. The temperature dependence of the distribution coefficient values has been utilised to determine the enthalpy of transfer, deltaHtr, and entropy of transfer deltaStr for the above process. From these results similar thermodynamic parameters for the transfer of different nonpolar side chains and peptide groups have been determined and compared with the available data in the literature.

摘要

已在不同温度下测定了甘氨酸、二甘氨酸、β-丙氨酸、丙氨酸、缬氨酸、正缬氨酸、亮氨酸和正亮氨酸的N-乙酰乙酯在水和不同有机溶剂之间的分配系数。还测定了简单酰胺、尿素、甲酰胺、乙酰胺和N-甲基乙酰胺的类似分配系数。通过分配测量，计算了溶质从有机溶剂转移到水中的自由能ΔGtr。利用分配系数值对温度的依赖性来确定上述过程的转移焓ΔHtr和转移熵ΔStr。根据这些结果，已确定了不同非极性侧链和肽基团转移的类似热力学参数，并与文献中的现有数据进行了比较。