局限于额内侧的致痫灶引发运动障碍行为和发笑。
Restricted frontomesial epileptogenic focus generating dyskinetic behavior and laughter.
作者信息
Chassagnon Serge, Minotti Lorella, Kremer Stephane, Verceuil Laurent, Hoffmann Dominique, Benabid Alim Louis, Kahane Philippe
机构信息
Service de Neurologie, Neuropsychologie et explorations fonctionnelles des épilepsies, hospices civils de Strasbourg, Strasbourg, France.
出版信息
Epilepsia. 2003 Jun;44(6):859-63. doi: 10.1046/j.1528-1157.2003.60802.x.
PURPOSE
Substantial data are missing about the anatomic location of frontal regions supporting gelastic seizures.
METHODS
We report the results of stereo-electro-encephalographic recordings performed over several distinct functional premotor and executive fields in a patient whose seizures were characterized by dyskinetic behavior and ictal laughter, in the absence of cerebral MRI abnormalities.
RESULTS
The epileptogenic zone was circumscribed in the anterior and ventral part of the supplementary motor area and the underlying dorsal cingulate cortex. There were no or little spreading to cortical neighboring areas. The patient is seizure-free (follow-up of 27 months) after a stereotactic electric radiofrequency lesion of the epileptogenic focus.
CONCLUSION
The present data suggest that pericingulate premotor areas are involved in the triggering of the motor component of laughter. In this case, the coexistence of paroxysmal dyskinesias during laughter might reflect the involvement of specific compartment(s) of the basal ganglia.
目的
关于支持痴笑性癫痫发作的额叶区域的解剖位置，大量数据缺失。
方法
我们报告了对一名患者在几个不同的功能性运动前区和执行区域进行立体脑电图记录的结果。该患者的癫痫发作表现为运动障碍行为和发作性笑，且脑部磁共振成像无异常。
结果
致痫区局限于辅助运动区的前部和腹侧以及其下方的背侧扣带回皮质。向邻近皮质区域的扩散不存在或很少。在对致痫灶进行立体定向射频毁损后，该患者无癫痫发作（随访27个月）。
结论
目前的数据表明，扣带回周围运动前区参与了笑的运动成分的触发。在这种情况下，笑时阵发性运动障碍的共存可能反映了基底神经节特定部分的参与。
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