补充胸苷酸合成酶。

Complementing thymidylate synthase.

作者信息

Montfort William R

出版信息

Structure. 2003 Jun;11(6):607-8. doi: 10.1016/s0969-2126(03)00101-1.

Abstract

The structure of thymidylate synthase complementing protein with substrates dUMP and FAD, presented in this issue of Structure, sheds light on a fascinating new catalytic mechanism, suggests a strategy for the design of new antimicrobial compounds, and highlights the promise of proteomics in medicine.

摘要

本期《结构》杂志发表的胸苷酸合成酶互补蛋白与底物二氢尿嘧啶核苷酸（dUMP）和黄素腺嘌呤二核苷酸（FAD）的结构，揭示了一种引人入胜的新催化机制，提出了设计新型抗菌化合物的策略，并突出了蛋白质组学在医学中的前景。