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正常大鼠和糖尿病大鼠完整肝细胞的脂肪生成

Lipogenesis by intact hepatocytes from normal and diabetic rats.

作者信息

Raghupathy E, Orthlieb C, Abraham S

出版信息

Lipids. 1975 Nov;10(11):653-5. doi: 10.1007/BF02532756.

DOI:10.1007/BF02532756
PMID:127915
Abstract

Intact hepatocytes isolated from livers of diabetic rats demonstrate the characteristic decreased lipogenic capacities as compared to normal. Administration of insulin to diabetic rats restores these capacities to near normal levels. The results emphasize the potential that the hepatocyte system has for the study of hormonal regulation of lipogenesis.

摘要

与正常大鼠相比，从糖尿病大鼠肝脏分离出的完整肝细胞表现出典型的脂肪生成能力下降。给糖尿病大鼠注射胰岛素可使这些能力恢复到接近正常水平。这些结果强调了肝细胞系统在研究脂肪生成激素调节方面的潜力。

相似文献

1
Lipogenesis by intact hepatocytes from normal and diabetic rats.正常大鼠和糖尿病大鼠完整肝细胞的脂肪生成
Lipids. 1975 Nov;10(11):653-5. doi: 10.1007/BF02532756.
2
Lipogenesis from ketone bodies in perfused livers from streptozocin-induced diabetic rats.链脲佐菌素诱导的糖尿病大鼠灌注肝脏中酮体的脂肪生成
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The regulation of lipogenesis by cyclic nucleotides in intact hepatocytes prepared by a simplified technique.通过一种简化技术制备的完整肝细胞中环核苷酸对脂肪生成的调节。
J Biol Chem. 1974 Feb 25;249(4):1286-94.
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Role of TPNH in fatty acid synthesis from acetate by normal and diabetic rat-liver homogenate fractions.三磷酸吡啶核苷酸（TPNH）在正常和糖尿病大鼠肝脏匀浆组分由乙酸合成脂肪酸过程中的作用
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Fatty acid synthesis from acetate by normal and diabetic rat liver homogenate fractions. I. A comparison of cofactor requirements.正常和糖尿病大鼠肝脏匀浆组分由乙酸盐合成脂肪酸。I. 辅因子需求的比较。
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Studies of the metabolism of isolated livers of normal and alloxan-diabetic rats perfused with insulin.对用胰岛素灌注的正常大鼠和四氧嘧啶糖尿病大鼠的离体肝脏代谢的研究。
Diabetes. 1968 May;17(5):244-50. doi: 10.2337/diab.17.5.244.

本文引用的文献

1
Two blocks in carbohydrate utilization in the liver of the diabetic rat.糖尿病大鼠肝脏碳水化合物利用中的两个障碍。
J Biol Chem. 1951 Jan;188(1):389-96.
2
FATTY ACID SYNTHESIS BY COMPLEX SYSTEMS. THE POSSIBILITY OF REGULATION BY MICROSOMES.复杂系统的脂肪酸合成。微粒体调节的可能性。
Biochim Biophys Acta. 1963 Dec 27;70:627-41. doi: 10.1016/0006-3002(63)90807-2.
3
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
4
Metabolic blocks in carbohydrate metabolism in diabetes.糖尿病中碳水化合物代谢的代谢障碍。
Harvey Lect. 1951;Series 47:99-125.
5
Glucose and acetate utilization by hyperplastic, alveolar nodule outgrowths and adenocarcinomas of mouse mammary gland.小鼠乳腺增生性、肺泡结节性增生及腺癌对葡萄糖和乙酸盐的利用情况。
Cancer Res. 1971 May;31(5):527-37.
6
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
7
Lipogenesis in rat hepatocytes.大鼠肝细胞中的脂肪生成
J Biol Chem. 1974 Apr 10;249(7):2028-36.
8
The regulation of lipogenesis by cyclic nucleotides in intact hepatocytes prepared by a simplified technique.通过一种简化技术制备的完整肝细胞中环核苷酸对脂肪生成的调节。
J Biol Chem. 1974 Feb 25;249(4):1286-94.
9
Protein synthesis in single cell suspensions from rat liver. I. General properties of the system and permeability of the cells for leucine and methionine.
J Biol Chem. 1972 Oct 10;247(19):6340-6.
10
The regulation of gluconeogenesis in isolated rat liver cells by glucagon, insulin, dibutyryl cyclic adenosine monophosphate, and fatty acids.胰高血糖素、胰岛素、二丁酰环磷酸腺苷和脂肪酸对离体大鼠肝细胞糖异生的调节
J Biol Chem. 1972 May 25;247(10):3229-35.