[Vasculogenesis and angiogenesis: molecular and cellular controls. II. The interactions between the cell and its environment].

Angiogenesis defined as a new blood vessel formation from a preexisting vessel is initiated by angiogenic growth factors and their receptors, that induce endothelial cells migration and proliferation. Extracellular proteolysis is essential for deassembly et reassembly of endothelial cells to their environmental matrix. The aim of this review is to update data upon the role of the coagulation and fibrinolysis system, metalloproteinases and adhesion molecules during this step of angiogenesis.