Tang Dean G, Conti Claudio J
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, TX 78957, USA.
Semin Thromb Hemost. 2004 Feb;30(1):109-17. doi: 10.1055/s-2004-822975.
In the embryo, blood vessel formation de novo (vasculogenesis) and from existing vessels (angiogenesis) results in blood vessels lined by endothelial cells (ECs). The relationship between ECs and blood cells suggested by their physical closeness was recently confirmed with the demonstration of progenitors that give rise to both cell types. In tumors, new blood vessel formation has been thought to occur primarily via angiogenesis. Recent evidence, however, suggests that postnatal vasculogenesis also contributes to tumor neovascularization. In this article, we provide an update on EC development, including early lineage specification, morphogenesis or differentiation to form functional blood vessels, and regulation of EC survival and senescence. Furthermore, we review the latest findings on tumor neovascularization and therapeutic potentials of molecules critical to this process.
在胚胎中，从头开始形成血管（血管生成）以及从现有血管形成血管（血管生成）会产生由内皮细胞（ECs）排列的血管。ECs与血细胞之间因物理上的紧密联系而暗示的关系，最近通过对产生这两种细胞类型的祖细胞的证明得到了证实。在肿瘤中，新血管形成一直被认为主要通过血管生成发生。然而，最近的证据表明，出生后的血管生成也有助于肿瘤新生血管形成。在本文中，我们提供了关于EC发育的最新进展，包括早期谱系特化、形态发生或分化以形成功能性血管，以及EC存活和衰老的调节。此外，我们回顾了关于肿瘤新生血管形成以及对这一过程至关重要的分子的治疗潜力的最新发现。
