Guimarey L, Moreno Morcillo A, Orazi V, Lemos-Marini S H V
Endocrinology and Growth Unit, Children's Hospital SSM Ludovica, Scientific Research Commission of the Buenos Aires Province, La Plata, Argentina.
J Pediatr Endocrinol Metab. 2003 Apr-May;16(4):541-4. doi: 10.1515/jpem.2003.16.4.541.
Bone age is widely used as an osseous maturation method to assess biological development in clinical and auxological studies. Numerical methods for calculating bone age have better replicability; however, they require a wide data manipulation. The aim of this study was to evaluate the accuracy of bone age estimation by using just a few ossification centers. In 205 hand and wrist radiographs of children and adolescents, aged 0.9-17.4 years old (111 males and 94 females), bone age was determined by two trained observers employing the five-bone (B5) and the TW2 methods. To compare the results of the two methods, the mean differences by age and sex were tested by the Mann-Whitney test. The relationship of the bone age distribution estimated by B5 and TW2 was calculated and the mean of the bone age determined by the two methods was plotted by age and by differences between bone age calculated by the two methods +/- 2 SD. The bone age determined by B5 was between 1.2 and 16.8, and by TW2 was between 1.2 and 18.0 years. The mean differences between B5 and TW2 (-0.06 +/- 0.6) were not significant (p > 0.05). The distribution of mean differences by age and method demonstrated that all deviations were encompassed into +/- 2 SD with no particular bias. In general terms, a good agreement was obtained between these two methods.
骨龄作为一种骨成熟度评估方法，在临床和发育学研究中被广泛用于评估生物发育情况。计算骨龄的数值方法具有更好的可重复性；然而，它们需要大量的数据处理。本研究的目的是评估仅使用少数几个骨化中心来估计骨龄的准确性。在205例年龄在0.9至17.4岁之间的儿童和青少年（111名男性和94名女性）的手部和腕部X光片中，由两名经过培训的观察者采用五骨（B5）法和TW2法确定骨龄。为比较两种方法的结果，采用Mann-Whitney检验对按年龄和性别划分的平均差异进行检验。计算B5法和TW2法估计的骨龄分布之间的关系，并按年龄以及两种方法计算的骨龄差异±2标准差绘制两种方法确定的骨龄平均值。B5法确定的骨龄在1.2至16.8岁之间，TW2法确定的骨龄在1.2至18.0岁之间。B5法和TW2法之间的平均差异（-0.06±0.6）不显著（p>0.05）。按年龄和方法划分的平均差异分布表明，所有偏差都包含在±2标准差范围内，无特定偏差。总体而言，这两种方法之间取得了良好的一致性。
