Giebel L B, Strunk K M, Holmes S A, Spritz R A
Department of Medical Genetics, University of Wisconsin, Madison 53706.
Oncogene. 1992 Nov;7(11):2207-17.
We have cloned and sequenced the human KIT proto-oncogene, which contains 21 exons and spans more than 34 kb of DNA on chromosome segment 4q12. We also establish physical linkage between the KIT gene and the related PDGFRA gene. The organization of the KIT gene is virtually identical to that of the homologous FMS gene, located on chromosome 5. Together, these data suggest that the KIT and PDGFRA genes on chromosome 4 and the FMS and PDGFRB genes on chromosome 5 arose by duplication of a common ancestral gene, followed by duplication of a chromosome.
我们克隆并测序了人类KIT原癌基因，该基因包含21个外显子，跨越4号染色体12区的34kb以上的DNA。我们还建立了KIT基因与相关的PDGFRA基因之间的物理连锁。KIT基因的结构与位于5号染色体上的同源FMS基因几乎相同。这些数据共同表明，4号染色体上的KIT和PDGFRA基因以及5号染色体上的FMS和PDGFRB基因是由一个共同祖先基因的复制产生的，随后发生了染色体复制。
