降钙素基因相关肽与甘丙肽免疫反应性在雌性大鼠盆腔和腰骶部背根神经节中的共存

Coexistence of calcitonin gene-related peptide and galanin immunoreactivity in female rat pelvic and lumbosacral dorsal root ganglia.

作者信息

Papka R E, McNeill D L

机构信息

Department of Anatomical Sciences, University of Oklahoma, Health Sciences Center, Oklahoma City 73190.

出版信息

Peptides. 1992 Jul-Aug;13(4):761-7. doi: 10.1016/0196-9781(92)90184-5.

DOI:10.1016/0196-9781(92)90184-5

PMID:1279631

Abstract

Coexistence of immunoreactivity for calcitonin gene-related peptide (CGRP) and galanin (GAL) was examined in varicose nerve endings in female rat pelvic paracervical ganglia (PG) and in perikarya of lumbosacral dorsal root ganglia (DRG). Varicose peptide-containing nerves were closely adjacent to somata of neurons in the PG, certain somata being virtually surrounded by immunoreactive varicosities. Some nerve endings were immunoreactive for either CGRP or GAL; in others, immunoreactivity for CGRP and GAL coexisted. Likewise, many perikarya in DRG were CGRP immunoreactive, fewer were GAL immunoreactive, and in some immunoreactivity for CGRP and GAL coexisted. The results suggest there are subpopulations of neuropeptide-containing sensory nerve endings in the PG; some contain CGRP, some contain GAL, and in some CGRP and GAL coexist. These substances contained in sensory nerve endings could have important roles in pelvic ganglionic functions.

摘要

在雌性大鼠盆腔子宫颈旁神经节（PG）的曲张神经末梢以及腰骶背根神经节（DRG）的神经元胞体中，检测了降钙素基因相关肽（CGRP）和甘丙肽（GAL）的免疫反应性共存情况。含肽的曲张神经与PG中的神经元胞体紧密相邻，某些胞体实际上被免疫反应性曲张体所包围。一些神经末梢对CGRP或GAL呈免疫反应性；在其他神经末梢中，CGRP和GAL的免疫反应性共存。同样，DRG中的许多神经元胞体对CGRP呈免疫反应性，对GAL呈免疫反应性的较少，并且在一些神经元胞体中CGRP和GAL的免疫反应性共存。结果表明，PG中存在含神经肽的感觉神经末梢亚群；一些含有CGRP，一些含有GAL，还有一些CGRP和GAL共存。感觉神经末梢中所含的这些物质可能在盆腔神经节功能中发挥重要作用。