鲨肌醇 I 及其 Val7 和 Ile7 类似物在 GPI 试验中的合成及生物活性
Synthesis and biological activity in the GPI test of scyliorhinin I and its Val7 and Ile7 analogs.
作者信息
Rolka K, Kupryszewski G, Janas P, Myszor J, Herman Z S
机构信息
Institute of Chemistry, University of Gdańsk, Poland.
出版信息
Pol J Pharmacol Pharm. 1992 Jan-Feb;44(1):79-85.
PMID:1279645
Abstract
Scyliorhinin I, a decapeptide, of tachykinin family, and its two analogs containing Val or Ile in position 7, have been synthesized using the solid-phase method, and tested for agonistic activity on isolated guinea pig ileum. Both analogs were slightly more active than scyliorhinin I, but they were significantly less potent than substance P.
摘要
鲨肌肽I，一种速激肽家族的十肽及其在第7位含有缬氨酸或异亮氨酸的两种类似物，已采用固相法合成，并在离体豚鼠回肠上测试了激动活性。两种类似物的活性均略高于鲨肌肽I，但它们的效价明显低于P物质。
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