人类发作性睡病中纹状体多巴胺能系统的改变。

Alteration of the striatal dopaminergic system in human narcolepsy.

作者信息

Eisensehr I, Linke R, Tatsch K, von Lindeiner H, Kharraz B, Gildehaus F J, Eberle R, Pollmacher T, Schuld A, Noachtar S

机构信息

Departments of Neurology, University of Munich, Germany.

出版信息

Neurology. 2003 Jun 10;60(11):1817-9. doi: 10.1212/01.wnl.0000069608.84542.46.

DOI:10.1212/01.wnl.0000069608.84542.46

PMID:12796537

Abstract

Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using 123I-(3-iodopropene-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane and 123I-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R > or = 0.844, p < or = 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.

摘要

纹状体D2/D3多巴胺能受体被认为在猝倒症中起作用。作者使用123I-(3-碘丙烯-2-基)-2β-甲氧羰基-3β-(4-氯苯基)托烷和123I-2-羟基-3-碘-6-甲氧基-([1-乙基-2-吡咯烷基]甲基)苯甲酰胺单光子发射计算机断层扫描(SPECT)，研究了7例发作性睡病患者和7例对照者的纹状体突触前多巴胺转运体和突触后D2受体。发作性睡病患者的D2受体结合增加(p = 0.017)，且与猝倒发作和睡眠发作的频率相关(R≥0.844，p≤0.017)。在发作性睡病/猝倒症患者体内，人类纹状体多巴胺能系统发生改变。