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丁酰胆碱酯酶与路易体痴呆认知功能障碍的进展

Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies.

作者信息

Perry Elaine, McKeith Ian, Ballard Clive

机构信息

Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK.

出版信息

Neurology. 2003 Jun 10;60(11):1852-3. doi: 10.1212/01.wnl.0000068336.84399.9e.

DOI:10.1212/01.wnl.0000068336.84399.9e
PMID:12796550
Abstract

Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyrylcholinesterase activity and the rate of cognitive decline in a prospectively studied, autopsy-confirmed dementia with Lewy bodies series.

摘要

丁酰胆碱酯酶与阿尔茨海默病的病理过程有关。在动物模型中，选择性抑制剂可增加乙酰胆碱并改善认知功能。在路易体痴呆中，胆碱能活性比在阿尔茨海默病中受影响更大。作者报告了在一项前瞻性研究的、经尸检确诊的路易体痴呆系列中，颞叶皮质丁酰胆碱酯酶活性与认知衰退率之间存在高度显著的关联。

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