Potter Tyler J, Summerlin Don-John, Campbell John H
Indiana University, Indianapolis, IN 46202, USA.
J Oral Maxillofac Surg. 2003 Jun;61(6):674-7. doi: 10.1053/joms.2003.50136.
This study was performed to assess the incidence of negative brush biopsy for oral lesions later demonstrated histologically to be squamous cell carcinoma.
All diagnoses of oral squamous cell carcinoma from a university oral pathology service for the period June 2000 through March 2002 were reviewed to determine if any had previously undergone brush biopsy reported to be "negative for epithelial abnormality." Those cases identified were further investigated to determine the time lapse between brush biopsy and definitive tissue diagnosis.
Four cases of brush biopsy negative squamous cell carcinoma were identified from 115 total cases of malignancy (3.5%). The average time from brush biopsy to tissue diagnosis was 117.25 days (range, 5 to 292 days).
False negative reports are possible with the oral brush biopsy technique. Persistent lesions should undergo tissue biopsy for definitive diagnosis.
本研究旨在评估口腔病变刷检活检结果为阴性，而组织学检查后来证实为鳞状细胞癌的发生率。
回顾了一所大学口腔病理科在2000年6月至2002年3月期间所有口腔鳞状细胞癌的诊断情况，以确定是否有病例之前接受过刷检活检，报告为“上皮异常阴性”。对确定的病例进一步调查，以确定刷检活检与最终组织诊断之间的时间间隔。
在115例恶性肿瘤病例中，共发现4例刷检活检阴性的鳞状细胞癌（3.5%）。从刷检活检到组织诊断的平均时间为117.25天（范围为5至292天）。
口腔刷检活检技术可能会出现假阴性报告。持续性病变应进行组织活检以明确诊断。
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