Rivers M B, Pulido J S, Folk J C
Department of Ophthalmology, University of Iowa, Iowa City.
Retina. 1992;12(2):90-5. doi: 10.1097/00006982-199212020-00003.
Seven patients with scars typical of ocular histoplasmosis syndrome presented with new symptoms of decreased vision or metamorphopsia. In each patient the symptoms corresponded to an atrophic or "punched-out" histoplasmosis scar in the macula. Clinically, a small amount of subretinal fluid overlying the scars and slight hyperfluorescence were seen on fluorescein angiography. These findings were due to a choroidal neovascular membrane growing within the margins of the atrophic scar. The membranes were difficult to diagnose because of the absence of hemorrhage, pigmentation, or growth of vessels beyond the margins of the scar. Clinicians should be aware that these patients may have early and growing choroidal neovascularization and may need to undergo photocoagulation or to be followed closely.
七名患有典型眼组织胞浆菌病综合征瘢痕的患者出现了视力下降或视物变形的新症状。每名患者的症状均与黄斑区萎缩性或“凿孔样”组织胞浆菌病瘢痕相对应。临床上，荧光素血管造影显示瘢痕上方有少量视网膜下液和轻微的荧光增强。这些表现是由于萎缩性瘢痕边缘内生长的脉络膜新生血管膜所致。由于没有出血、色素沉着或血管超出瘢痕边缘生长，这些膜很难诊断。临床医生应意识到这些患者可能有早期且正在发展的脉络膜新生血管形成，可能需要进行光凝治疗或密切随访。
