铁负荷对异烟肼或乙胺丁醇治疗小鼠结核病活性的影响。
Impact of iron loading on the activity of isoniazid or ethambutol in the treatment of murine tuberculosis.
作者信息
Lounis N, Maslo C, Truffot-Pernot C, Grosset J, Boelaert R J
机构信息
Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
出版信息
Int J Tuberc Lung Dis. 2003 Jun;7(6):575-9.
OBJECTIVE
To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis.
DESIGN
Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days.
RESULTS
For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited.
CONCLUSION
The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
目的
评估铁负荷对异烟肼和乙胺丁醇治疗小鼠结核病活性的影响。
设计
用1.5×10⁷结核分枝杆菌菌落形成单位感染的铁负荷和铁正常的雌性Balb/C小鼠，分别用异烟肼或乙胺丁醇治疗28天。
结果
对于两种治疗，铁负荷均损害了治疗效果：异烟肼的杀菌活性部分但显著降低，乙胺丁醇的杀菌活性完全被抑制。
结论
铁负荷患者的结核病治疗时间应比正常患者更长，或应包含一种额外的药物。
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