一种使用构象受限半抗原改进尼古丁疫苗的新策略。
A new strategy for improved nicotine vaccines using conformationally constrained haptens.
作者信息
Meijler Michael M, Matsushita Masayuki, Altobell Laurence J, Wirsching Peter, Janda Kim D
机构信息
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
J Am Chem Soc. 2003 Jun 18;125(24):7164-5. doi: 10.1021/ja034805t.
PMID:12797775
Abstract
Constrained nicotine analogues were synthesized and coupled to the carrier protein KLH. The immunogenic effects were compared to those using our previously designed flexible nicotine hapten. Immunization of mice with the constrained hapten conjugates resulted in highly increased antibody titers and affinity for nicotine.
摘要
合成了受限尼古丁类似物并将其与载体蛋白钥孔血蓝蛋白（KLH）偶联。将免疫原性效应与使用我们之前设计的柔性尼古丁半抗原所产生的效应进行了比较。用受限半抗原缀合物免疫小鼠导致抗体滴度和对尼古丁的亲和力大幅提高。
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