Sosa Henríquez M, Saavedra Santana P, Alegre López J, Gómez Alonso C, González Macías J, Guañabens Gay N, Hawkins Carranza F, Lozano Tonkin C, Martínez Izquierdo M T, Mosquera Martínez J, Muñoz Torres M, Pérez Cano R, Quesada Gómez J M, Salas Heredia E
Unidad Metabólica Osea. Departamento de Ciencias Médicas y Quirúrgicas. Servicio de Medicina Interna. Hospital Universitario Insular. Universidad de Las Palmas de Gran Canaria. Spain.
Rev Clin Esp. 2003 Jul;203(7):329-33. doi: 10.1157/13047946.
In recent years, a large number of techniques have been developed to estimate the bone mineral density for the diagnosis of osteoporosis. However, diagnostic criteria established by WHO are invariably applied for the interpretation of dual radiological densitometry (DEXA), which could not be correct in the case of the interpretation of ultrasound.
We studied 2,589 randomly chosen people of both sexes, 1,138 males and 1,451 women from 10 to 99 years, in 11 spanish provinces. We carried out a measurement of the following calcaneous ultrasound parameters with the Sahara and Hologic devices: speed of the sound (SOS), coefficient of attenuation of wide band (BUA), index of consistency (QUI) and estimated bone mineral density (est. BMD). The prevalence of osteopenia and osteoporosis was calculated by applying the WHO criteria (osteopenia Tscore < or = 1 and osteoporosis Tscore < or = 2.5) and the prevalence of osteoporosis by applying a Tscore 1.8 as threshold.
According to the WHO criteria, osteoporosis (Tscore < or = 2.5) is seen in 1.5 % males and 5.9 % females from 51 to 70 years, and in 2.6% males and 22.1% females over 70 years. Using a Tscore 1.8 as threshold, osteoporosis prevalence increases to 8.2% males and 21.9% females from 51 to 70 years, and to 8.4% males and 40.9% females over 70 years.
Osteoporosis prevalence in spanish people of both sexes differs notably when applying the cut off point in a Tscore of 2.5, as WHO recommends, or in a Tscore of 1.8 as is suggested by other authors. Consensus is necessary to establish the appropriate cut off point or threshold for the diagnosis of osteoporosis with quantitative ultrasonography of calcaneum.
近年来,已开发出大量技术用于估计骨矿物质密度以诊断骨质疏松症。然而,世界卫生组织(WHO)制定的诊断标准一直被用于双能X线骨密度仪(DEXA)的解读,而在超声解读的情况下这可能并不正确。
我们在西班牙11个省份对2589名随机选取的男女进行了研究,其中男性1138名,女性1451名,年龄在10至99岁之间。我们使用Sahara和Hologic设备对以下跟骨超声参数进行了测量:声速(SOS)、宽带衰减系数(BUA)、一致性指数(QUI)和估计骨矿物质密度(est. BMD)。通过应用WHO标准(骨量减少T值≤ -1,骨质疏松症T值≤ -2.5)计算骨量减少和骨质疏松症的患病率,并以T值1.8为阈值计算骨质疏松症的患病率。
根据WHO标准,51至70岁的男性中骨质疏松症(T值≤ -2.5)的患病率为1.5%,女性为5.9%;70岁以上男性为2.6%,女性为22.1%。以T值1.8为阈值,51至70岁男性骨质疏松症患病率增至8.2%,女性增至21.9%;70岁以上男性为8.4%,女性为40.9%。
当采用WHO推荐的T值2.5或其他作者建议的T值1.8作为切点时,西班牙男女骨质疏松症患病率存在显著差异。有必要达成共识,以确定跟骨定量超声检查诊断骨质疏松症的合适切点或阈值。