Allan Douglas W, Thor Stefan
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Neuron. 2003 Jun 5;38(5):675-7. doi: 10.1016/s0896-6273(03)00329-5.
bHLH and LIM-HD transcription factors were originally thought to act at different stages of neurogenesis: bHLHs as neuronal "inducers" and LIM-HDs as postmitotic subtype determinants. These distinctions are becoming blurred, and a current study by Lee and Pfaff in this issue of Neuron shows that interaction between these factors functions to synchronize neurogenesis with neuronal cell type specification.
bHLH和LIM-HD转录因子最初被认为在神经发生的不同阶段发挥作用：bHLH作为神经元的“诱导因子”，而LIM-HD作为有丝分裂后亚型的决定因素。这些区别正变得模糊，Lee和Pfaff在本期《神经元》上发表的一项最新研究表明，这些因子之间的相互作用起到使神经发生与神经元细胞类型特化同步的作用。
