Schnabel T, Zamboglou N, Kuhn F P, Kolotas C, Schmitt G
Department of Radiation Oncology, Heinrich-Heine-University, Düsseldorf.
Strahlenther Onkol. 1992 Oct;168(10):584-7.
Palliative treatment of recurrent rectal cancer remains to be a challenge. From 1989 to 1991 13 patients with recurrent rectal cancer were treated with intraarterial infusion of 5-Fluorouracil and simultaneous radiotherapy in a palliative intent. Seven patients had received postoperative adjuvant radiotherapy with 56 to 60 Gy. Three patients had been treated with systemic chemotherapy. Radiotherapy of the recurrence was performed with 19.8 to 30.6 Gy in the pre-irradiated patients and with 50.4 to 59.4 Gy in the others. One complete remission, three partial remissions and nine minor responses were observed. Three patients had complete pain relief after the treatment, in the remaining patients major pain reduction was achieved. Palliation lasted from three to twelve months (median: five months). Our results indicate that locoregional chemo- and radiotherapy are a effective modality in recurrent rectal cancer.
复发性直肠癌的姑息治疗仍然是一项挑战。1989年至1991年，13例复发性直肠癌患者接受了动脉内输注5-氟尿嘧啶并同时进行姑息性放疗。7例患者术后接受了56至60 Gy的辅助放疗。3例患者接受了全身化疗。复发部位的放疗，先前接受过放疗的患者剂量为19.8至30.6 Gy，其他患者为50.4至59.4 Gy。观察到1例完全缓解、3例部分缓解和9例轻度缓解。3例患者治疗后疼痛完全缓解，其余患者疼痛明显减轻。姑息治疗持续3至12个月（中位数：5个月）。我们的结果表明，局部化疗和放疗是复发性直肠癌的一种有效治疗方式。
