（±）-2-（3-哌啶基）-1,2,3,4-四氢异喹啉类作为一类新型的特异性心动过缓药物。
(+/-)-2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinolines as a new class of specific bradycardic agents.
作者信息
Kubota Hideki, Kakefuda Akio, Watanabe Toshihiro, Taguchi Yasuko, Ishii Noe, Masuda Noriyuki, Sakamoto Shuichi, Tsukamoto Shin ichi
机构信息
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., 21Miyukigaoka, Tsukuba, 305-8585, Ibaraki, Japan.
出版信息
Bioorg Med Chem Lett. 2003 Jul 7;13(13):2155-8. doi: 10.1016/s0960-894x(03)00349-4.
A series of (+/-)-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinolines were prepared and their bradycardic activities were examined in isolated guinea-pigs' right atria and in anesthetized rats. Modifications on the benzyl moiety of the parent compound, 1, led to the identification of compound 11e as a potent and specific bradycardic agent.
制备了一系列（±）-2-（3-哌啶基）-1,2,3,4-四氢异喹啉，并在离体豚鼠右心房和麻醉大鼠中检测了它们的心动过缓活性。对母体化合物1的苄基部分进行修饰，确定化合物11e为一种强效且特异性的心动过缓剂。
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