Fracchioli S, Porpiglia M, Arisio R, Voglino G, Katsaros D
Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, University of Turin, Turin, Italy.
Gynecol Oncol. 2003 Jun;89(3):522-5. doi: 10.1016/s0090-8258(03)00129-x.
Cervical cancer usually spreads by direct infiltration and disseminates by lymphatic and hematogenous pathways. The common sites of distant metastases are the lungs, liver, and bones. Other rare metastatic sites have been previously described including only one case of oral cavity metastasis.
We present here the second case of a patient with apparent oral cavity metastasis from cervical cancer. By cloning specific human papilloma virus (HPV) genomic regions, the two lesions showed HPV genomic sequences from different viruses (18 and 33, for the uterine cervix and the oral cavity, respectively), thus indicating the oral lesion as a synchronous second primary tumor.
The use of molecular markers to distinguish between a secondary and a primary lesion is recommendable in cervical cancer, particularly when reporting rare site metastases.
宫颈癌通常通过直接浸润扩散，并通过淋巴和血行途径播散。远处转移的常见部位是肺、肝和骨。先前已描述过其他罕见的转移部位，包括仅1例口腔转移病例。
我们在此报告第二例宫颈癌出现明显口腔转移的患者。通过克隆特定的人乳头瘤病毒（HPV）基因组区域，两个病变显示出来自不同病毒（分别为子宫颈的18型和口腔的33型）的HPV基因组序列，因此表明口腔病变是同步发生的第二原发性肿瘤。
在宫颈癌中，尤其是报告罕见部位转移时，建议使用分子标记来区分继发性和原发性病变。
