Singh Ranger G, Mokbel K
St George's Hospital and Medical School, Blackshaw Road, London SW17 0QT, UK.
Eur J Surg Oncol. 2003 Jun;29(5):423-5. doi: 10.1016/s0748-7983(03)00038-6.
Recent studies have demonstrated that the sentinal node biopsy (SNB), which utilizes a simple principle, is a reliable and minimally invasive method for determining the status of the regional lymph nodes in patients with clinically node-negative breast cancer. The technique has been widely used in the management of patients with early breast cancer despite the lack of long-term data from randomised controlled trials which are currently in progress. The present article reviews the role of the SNB in the context of axillary node sampling and determines the requirements for its safe clinical application. It also highlights the need for further research to clarify the role of the SNB in high risk DCIS, the value of preoperative lymphascintigraphy, and the clinical relevance of internal mammary node dissection and focused examination of the sentinal node by immunohistochemistry and polymerase chain reaction.
近期研究表明,前哨淋巴结活检(SNB)采用简单原理,是确定临床腋窝淋巴结阴性乳腺癌患者区域淋巴结状态的可靠且微创方法。尽管目前正在进行的随机对照试验缺乏长期数据,但该技术已广泛应用于早期乳腺癌患者的治疗。本文回顾了前哨淋巴结活检在腋窝淋巴结取样背景下的作用,并确定其安全临床应用的要求。文章还强调了进一步研究的必要性,以阐明前哨淋巴结活检在高危导管原位癌中的作用、术前淋巴闪烁造影的价值、内乳淋巴结清扫的临床相关性以及通过免疫组织化学和聚合酶链反应对前哨淋巴结进行重点检查的临床意义。