[静脉注射免疫球蛋白的治疗指征]

[Therapeutic indications of intravenous immunoglobulins].

作者信息

Tellier Z, Mouthon L

机构信息

Laboratoire du fractionnement et des biotechnologies, direction des affaires médicales et de la recherche clinique, 3, avenue des Tropiques, BP 305, 91958 cedex, Les Ulis, France.

出版信息

Transfus Clin Biol. 2003 Jun;10(3):179-84. doi: 10.1016/s1246-7820(03)00043-0.

DOI:10.1016/s1246-7820(03)00043-0

PMID:12798854

Abstract

Intravenous Immunoglobulin (IVIg) provide a wide spectrum of antibody specificities in patients with antibody deficiencies and restore immune homeostasis in patients with auto-immune diseases. Controlled trials have now been performed in a large number of diseases: in primary and secondary antibody deficiencies, auto-immune neurological diseases and various other auto-immune or systemic inflammatory conditions. Mechanisms of action of IVIg are multiple and often associated for a given disease. These mechanisms are however incompletely understood and therapeutic effect of IVIg remains to be investigated in a wide range of diseases.

摘要

静脉注射免疫球蛋白（IVIg）为抗体缺乏患者提供广泛的抗体特异性，并在自身免疫性疾病患者中恢复免疫稳态。目前已在大量疾病中进行了对照试验：原发性和继发性抗体缺乏症、自身免疫性神经疾病以及各种其他自身免疫或全身性炎症性疾病。IVIg的作用机制是多方面的，并且在特定疾病中常常相互关联。然而，这些机制尚未完全明了，IVIg在广泛疾病中的治疗效果仍有待研究。