静脉注射免疫球蛋白的供应、使用及滥用

Supply, use, and abuse of intravenous immunoglobulin.

作者信息

Nowak-Wegrzyn A, Lederman H M

机构信息

Johns Hopkins University School of Medicine, Department of Pediatrics, Eudowood Division of Allergy and Immunology, Baltimore, Maryland 21287-3923, USA.

出版信息

Curr Opin Pediatr. 1999 Dec;11(6):533-9. doi: 10.1097/00008480-199912000-00011.

DOI:10.1097/00008480-199912000-00011

PMID:10590912

Abstract

Intravenous immunoglobulin is used as a replacement therapy in primary immunodeficiency diseases as well as an immunomodulatory agent in a variety of autoimmune and inflammatory disorders. The mechanisms of intravenous immunoglobulin action are complex and, for some disorders, not well understood. This paper reviews the recent literature and discusses approved, new, and controversial indications for intravenous immunoglobulin therapy, with special emphasis on its mechanism of action.

摘要

静脉注射免疫球蛋白在原发性免疫缺陷疾病中用作替代疗法，同时在多种自身免疫性和炎症性疾病中用作免疫调节剂。静脉注射免疫球蛋白的作用机制复杂，对于某些疾病，其作用机制尚不完全清楚。本文综述了近期文献，并讨论了静脉注射免疫球蛋白治疗的已批准、新的和有争议的适应症，特别强调了其作用机制。