子宫内膜的局部损伤使接受体外受精的患者成功怀孕的几率增加一倍。
Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
作者信息
Barash Amihai, Dekel Nava, Fieldust Sheila, Segal Ilana, Schechtman Edna, Granot Irit
机构信息
IVF Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Israel.
出版信息
Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.
OBJECTIVE
Exploration of the possibility that local injury of the endometrium increases the incidence of implantation.
DESIGN
Prospective study.
SETTING
Clinical IVF unit.
PATIENT(S): A group of 134 patients, defined as good responders to hormonal stimulation, who failed to conceive during one or more cycles of IVF and embryo transfer (ET).
INTERVENTION(S): The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 45 of a total of 134 patients.
MAIN OUTCOME MEASURES
Outcome of IVF-ET treatments.
RESULT(S): Transfer of a similar number of embryos (3.4 +/- 1.0 and 3.1 +/- 0.9 in the experimental and control patients, respectively) resulted in rates of implantation (27.7% vs. 14.2%, P =.00011), clinical pregnancy (66.7% vs. 30.3%, P =.00009), and live births per ET (48.9% vs. 22.5%, P =.016) that were more than twofold higher in the experimental group as compared to controls.
CONCLUSION(S): These results suggest that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
目的
探讨子宫内膜局部损伤增加着床率的可能性。
设计
前瞻性研究。
地点
临床体外受精科室。
患者
一组134例患者，定义为对激素刺激反应良好者，在一个或多个体外受精和胚胎移植（ET）周期中未能受孕。
干预措施
在134例患者中随机选择45例，在体外受精治疗和胚胎移植前进行反复子宫内膜活检。
主要观察指标
体外受精-胚胎移植治疗的结果。
结果
移植相似数量的胚胎（试验组和对照组分别为3.4±1.0和3.1±0.9），试验组的着床率（27.7%对14.2%，P = 0.00011）、临床妊娠率（66.7%对30.3%，P = 0.00009）和每次胚胎移植的活产率（48.9%对22.5%，P = 0.016）比对照组高出两倍多。
结论
这些结果表明，在体外受精治疗前进行子宫内膜活检可使抱婴回家的机会增加一倍。
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