Danilewicz M, Kałuzyński A, Wagrowska-Danilewicz M, Bechcińska B, Zabicka H
Zakładu Anatomii Patologicznej Ak. Med., Lodzi.
Wiad Lek. 1992 Jun;45(11-12):433-5.
The clinical and morphological analysis is reported of the changes evolving in 12 cases of mesangial proliferative glomerulonephritis based on repeated biopsies carried out at intervals from 1 to 7 years. Clinical findings at the time of the first biopsy included in 2 cases nephrotic syndrome, and in the remaining cases proteinuria ranging from 0.3 to 2/1000. In all cases erythrocytes in urine were present ranging from 4-6 to 50-100 erythrocytes per field of vision. Hypertension was found in 4 cases, and increased serum creatinine level in 1 patient. At the time of repeated biopsy in 11 cases clinical evidence of improvement was noted with decreased proteinuria anderythrocytes in urine. In 1 case worsening was found and several months later signs of renal failure developed which led to death. The morphological examinations demonstrated in the first biopsies mesangial proliferative glomerulonephritis. In second biopsies these findings were confirmed. In 1 case with unfavourable outcome the changes became more pronounced, and in the remaining ones no significant differences were noted in relation to the first biopsy which evidenced lack of a close correlation between the clinical condition and the morphological state of the kidneys.
报告了12例系膜增生性肾小球肾炎患者的临床和形态学分析结果，这些分析基于间隔1至7年进行的多次活检。首次活检时的临床发现包括2例肾病综合征，其余病例蛋白尿范围为0.3至2/1000。所有病例尿中均有红细胞，每视野4 - 6至50 - 100个红细胞。4例发现高血压，1例患者血清肌酐水平升高。在重复活检时，11例有临床改善证据，蛋白尿和尿红细胞减少。1例病情恶化，数月后出现肾衰竭体征并导致死亡。形态学检查在首次活检时显示为系膜增生性肾小球肾炎。第二次活检证实了这些发现。1例预后不良的病例变化更为明显，其余病例与首次活检相比无显著差异，这表明临床状况与肾脏形态状态之间缺乏密切相关性。
