Partaledis J A, Fleming M A, Harding M W, Berlin V
Vertex Pharmaceuticals Inc., Cambridge, MA 02139-4211.
Yeast. 1992 Aug;8(8):673-80. doi: 10.1002/yea.320080812.
FKB2 encodes a homolog of human FKBP-13, a membrane-associated binding protein for the immunosuppressants FK506 and rapamycin. FKB2 is located on the right arm of chromosome IV and contains an open reading frame of 135 amino acids, of which the first 17 residues comprise a putative hydrophobic leader peptide. Yeast FKBP-13 is homologous to human FKBP-13 (52% amino acid identity) and to FKBP-12, the major cytosolic receptor for FK506. In the alignment of FKBP-13 and FKBP-12 sequences, there are 28 invariant residues. Among these conserved residues are those that comprise the drug binding and peptidyl-prolyl cis-trans isomerase active site of FKBP-12. The phylogenetic conservation of the FKBP family suggest that the proteins are involved in a basic cellular function.
FKB2编码人FKBP - 13的同源物，FKBP - 13是免疫抑制剂FK506和雷帕霉素的膜相关结合蛋白。FKB2位于第四条染色体的右臂上，包含一个由135个氨基酸组成的开放阅读框，其中前17个残基构成一个假定的疏水前导肽。酵母FKBP - 13与人FKBP - 13同源（氨基酸同一性为52%），并与FK506的主要胞质受体FKBP - 12同源。在FKBP - 13和FKBP - 12序列比对中，有28个不变残基。这些保守残基中包括构成FKBP - 12药物结合和肽基 - 脯氨酰顺反异构酶活性位点的残基。FKBP家族的系统发育保守性表明这些蛋白质参与一种基本的细胞功能。
