Ohmori H
Department of Physiology, Faculty of Medicine, Kyoto University, Japan.
Adv Biophys. 1992;28:1-30. doi: 10.1016/0065-227x(92)90021-i.
Auditory and vestibular information is applied to the hair cell hair bundle as mechanical energy, and is transduced into electrical energy by gating ion channels. The m-e.t. channel has a unitary conductance of 50 pS and a broad selectivity to monovalent cations and to divalent cations. Ca ions are the most permeable through the channel. The angular displacement of the hair bundle is the primary gating factor. Circumstantial evidence indicates the possibility of the direct gating of channels by the membrane deformation itself. The transduction potential activates voltage gated Ca channel and leads to the release of neurotransmitters which activate afferent neurones. Cholinergic muscarinic receptors likely mediate the inhibitory efferent innervation to the hair cell.
听觉和前庭信息以机械能的形式作用于毛细胞的毛束，并通过门控离子通道转化为电能。m-e.t.通道的单位电导为50 pS，对单价阳离子和二价阳离子具有广泛的选择性。钙离子是通过该通道最易通透的离子。毛束的角位移是主要的门控因素。间接证据表明通道可能由膜变形本身直接门控。转导电位激活电压门控钙通道并导致神经递质释放，从而激活传入神经元。胆碱能毒蕈碱受体可能介导对毛细胞的抑制性传出神经支配。
