Watanabe Naoto, Cheng Gang, Fukuda Takeshi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine.
Arerugi. 2003 May;52(5):485-91.
Some patients with bronchial asthma have increased cough sensitivity. In such patients coughing may be an inducer of wheeze. The aim of the present study was to investigate the effect of Bakumondo-to on the cough sensitivity and respiratory tract inflammation in asthmatic patients with increased cough sensitivity. In addition influences of intensity of respiratory tract inflammation, gender, type of asthma, and disease period on the effect of Bakumondo-to on the cough sensitivity were examined. Twenty-one bronchial asthmatics whose cough thresholds to capsaicin were less than 3.9 microM were examined.
Cough thresholds to capsaicin (concentration of inhaled capsaicin solution causing 5 or more coughs) was measured before and after 2 months or more treatment with Bakumondo-to (9 g/day, TJ-29). Number of eosinophils in peripheral blood, sputum eosinophil ratio, and ECP level in the serum were also measured before and after treatment.
Bakumondo-to significantly increased the cough threshold. Although respiratory tract inflammation was not significantly improved, number of eosinophils in peripheral blood, sputum eosinophil ratio and ECP level in the serum were remarkably decreased more than the half. And Bakumondo-to was more effective in asthmatic subjects with severe airway inflammation. Furthermore, a greater effect of it was observed in women. A greater effect was also observed in patients having a disease duration of less than 1 year.
Our results suggest that Bakumondo-to may be an effective therapeutic preparation for coughing in asthmatic patients with cough hypersensitivity.
一些支气管哮喘患者的咳嗽敏感性增加。在这些患者中，咳嗽可能是喘息的诱发因素。本研究的目的是探讨八味地黄丸对咳嗽敏感性增加的哮喘患者的咳嗽敏感性和呼吸道炎症的影响。此外，还研究了呼吸道炎症强度、性别、哮喘类型和病程对八味地黄丸咳嗽敏感性影响的作用。对21名对辣椒素咳嗽阈值低于3.9微摩尔的支气管哮喘患者进行了检查。
在用八味地黄丸（9克/天，TJ-29）治疗2个月或更长时间前后，测量对辣椒素的咳嗽阈值（吸入辣椒素溶液浓度引起5次或更多次咳嗽）。还在治疗前后测量外周血嗜酸性粒细胞数量、痰液嗜酸性粒细胞比例和血清中嗜酸性粒细胞阳离子蛋白（ECP）水平。
八味地黄丸显著提高了咳嗽阈值。虽然呼吸道炎症没有显著改善，但外周血嗜酸性粒细胞数量、痰液嗜酸性粒细胞比例和血清中ECP水平显著降低了一半以上。八味地黄丸对气道炎症严重的哮喘患者更有效。此外，在女性中观察到更大的效果。在病程小于1年的患者中也观察到更大的效果。
我们的结果表明，八味地黄丸可能是治疗咳嗽敏感性增加的哮喘患者咳嗽的有效治疗制剂。
