Yoshida K
Department of Oral and Maxillofacial Surgery, Kyoto University, Sakyoku, Japan.
Nervenarzt. 2003 Jun;74(6):516-22. doi: 10.1007/s00115-003-1508-3. Epub 2003 May 13.
Oromandibular dystonia is a neuromuscular disorder characterized by tonic or clonic involuntary spasms of the masticatory and lingual muscles. We treated 50 patients with this movement disorder by injection of lidocaine and alcohol into the masticatory or tongue muscles to block muscle afferents from muscle spindle. The patients were divided according to clinical features into four groups: jaw-closing, jaw-opening, jaw-deviation, and tongue dystonias. Objective evaluation of the symptoms before and after therapy was based on a clinical scaling protocol in terms of four parameters (mastication, speech, pain, and discomfort scales). Symptoms improved in all patients without major side effects. The overall objective improvement (60.2+/-29.5%) was significantly (P<0.005, ANOVA) lower in tongue dystonia (14.1%) than in jaw-closing dystonia (67.6%) and jaw-opening dystonia (68.3%). Although the response of the muscle afferent block to tongue dystonia was hardly satisfactory, this treatment is suggested to be effective for oromandibular dystonia.
口下颌肌张力障碍是一种神经肌肉疾病,其特征为咀嚼肌和舌肌出现强直性或阵挛性不自主痉挛。我们通过向咀嚼肌或舌肌注射利多卡因和酒精以阻断来自肌梭的肌肉传入神经,对50例患有这种运动障碍的患者进行了治疗。根据临床特征将患者分为四组:闭口型、开口型、偏颌型和舌型肌张力障碍。治疗前后症状的客观评估基于一项临床评分方案,该方案涉及四个参数(咀嚼、言语、疼痛和不适量表)。所有患者的症状均有改善,且无重大副作用。总体客观改善率(60.2±29.5%)在舌型肌张力障碍(14.1%)中显著(P<0.005,方差分析)低于闭口型肌张力障碍(67.6%)和开口型肌张力障碍(68.3%)。尽管肌肉传入神经阻滞对舌型肌张力障碍的反应几乎不尽人意,但这种治疗方法被认为对口下颌肌张力障碍有效。