Welling Karen-Lise, Taaning Ellen, Lund Birgit V, Rosenkvist Jørgen, Heslet Lars
Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Eur J Haematol. 2003 Jul;71(1):68-71. doi: 10.1034/j.1600-0609.2003.00092.x.
A 47-yr-old female with acute pancreatitis received four units of fresh frozen plasma because of subtle signs of disseminated intravascular coagulation (DIC). Seven days later, she developed severe thrombocytopenia. Serological studies demonstrated antibodies against HPA-1a together with pan-reactive antibodies against platelet glycoproteins (GPIIb-IIIa, GPIb-IX and GPIa-IIa), which was consistent with the diagnosis of PTP. The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values.
一名47岁患有急性胰腺炎的女性因存在弥散性血管内凝血（DIC）的细微迹象而接受了4单位新鲜冰冻血浆。7天后，她出现了严重的血小板减少症。血清学研究显示存在抗HPA-1a抗体以及针对血小板糖蛋白（GPIIb-IIIa、GPIb-IX和GPIa-IIa）的全反应性抗体，这与血小板输注后紫癜（PTP）的诊断相符。该患者接受了血小板输注、皮质类固醇和静脉注射免疫球蛋白（IVIG）治疗，但未获得永久性有益效果。经过血浆置换治疗后，血小板计数升至正常水平。
