Zubairi F, Novotný I
Physiol Bohemoslov. 1975;24(6):521-8.
The authors studied the effect of pyruvate and oleate on O2 consumption of the frog sartorius and heart ventricle. 10 mM pyruvate raised O2 consumption of both tissues by over 100%, but only in the winter. Raised O2 consumption was only partly associated with glycogen synthesis from pyruvate. 0.1 mM oleate reduced O2 consumption in both tissues. A marked drop in O2 consumption was observed in the ventricle (up to 50%). Lecithin had a similar effect on O2 consumption. The addition of pyruvate plus oleate led to an 8-fold increase in O2 consumption of the ventricle, i.e. to maximum oxidation capacity of the tissue, but the addition of lecithin inhibited the pyruvate-induced increase in O2 consumption. It is assumed that both pyruvate and oleate influence resting metabolism in a specific manner which cannot be attributed solely to raised availability of substrate for resting energy metabolism requirements.
作者研究了丙酮酸和油酸对青蛙缝匠肌和心室氧消耗的影响。10 mM丙酮酸使两种组织的氧消耗在冬季时增加了100%以上，但仅在冬季如此。氧消耗的增加仅部分与丙酮酸合成糖原有关。0.1 mM油酸降低了两种组织的氧消耗。在心室中观察到氧消耗显著下降（高达50%）。卵磷脂对氧消耗有类似影响。添加丙酮酸加油酸导致心室氧消耗增加8倍，即达到组织的最大氧化能力，但添加卵磷脂抑制了丙酮酸诱导的氧消耗增加。据推测，丙酮酸和油酸均以特定方式影响静息代谢，这不能仅仅归因于为满足静息能量代谢需求而增加的底物可用性。
