Doutremepuich J D, Barbier A, Vilain P, Lacheretz F
Department of General Pharmacology, Sanofi Recherche, Montpellier, France.
Skin Pharmacol. 1992;5(3):171-6. doi: 10.1159/000211034.
The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar9Met(O2)11-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B2-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar9Met(O2)11-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.
本研究的目的是评估几种药物对豚鼠皮肤中皮内注射P物质（SP）和Sar9Met（O2）11 - SP所诱导的皮肤毛细血管通透性增加的影响。一方面，spantide、异丙嗪、阿托品或血管紧张素转换酶抑制剂SR 40037可部分降低皮肤毛细血管通透性的增加。另一方面，去甲肾上腺素和缓激肽的B2拮抗剂B3824显示出增强作用。我们的结果表明，SP和Sar9Met（O2）11 - SP在豚鼠中的作用部分由组胺和乙酰胆碱介导，并且速激肽与缓激肽之间存在关联。
