抗吗啡抗体对海马体突触可塑性的影响。

Effect of antibodies to morphine on synaptic plasticity of the hippocampus.

作者信息

Beregovoi N A, Pankova T M, Sorokina N S, Starostina M V

机构信息

Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.

出版信息

Bull Exp Biol Med. 2003 Feb;135(2):114-6. doi: 10.1023/a:1023895109474.

DOI:10.1023/a:1023895109474

PMID:12802411

Abstract

Incubation of hippocampal slices with antibodies to morphine did not change the total excitatory postsynaptic potential of mossy fibers, but markedly facilitated long-term posttetanic potentiation. Culturing of the organotypic hippocampal culture in the presence of 10 microM morphine increased the total excitatory postsynaptic potential of mossy fibers and reduced the probability of long-term posttetanic potentiation.

摘要

用吗啡抗体孵育海马切片不会改变苔藓纤维的总兴奋性突触后电位，但会显著促进强直后长时程增强。在10微摩尔吗啡存在的情况下培养器官型海马培养物会增加苔藓纤维的总兴奋性突触后电位，并降低强直后长时程增强的概率。