乙酰胆碱和三磷酸腺苷通过激活不同类型的钙激活钾通道使内皮超极化。
Acetylcholine and ATP hyperpolarize endothelium via activation of different types of Ca(2+)-activated K+ channels.
作者信息
Marchenko S M
机构信息
A. A. Bogomolets Institute of Physiology, National Academy of Science of Ukraine, Kiev.
出版信息
Bull Exp Biol Med. 2002 Nov;134(5):422-4. doi: 10.1023/a:1022665625110.
PMID:12802439
Abstract
Experiments on rat thoracic aorta showed that ATP and acetylcholine hyperpolarize endothelial cell via selective activation of low (SK) and intermediate (IR) conductance Ca(2+)-activated K(+)channels, respectively. It was hypothesized that ATP- and acetylcholine-activated Ca(2+)-signals are spatially separated and generated in plasma membrane regions with predominant localization of SK- and IR-channels, respectively.
摘要
对大鼠胸主动脉的实验表明，ATP和乙酰胆碱分别通过选择性激活低电导（SK）和中电导（Ca2+）激活的钾通道，使内皮细胞超极化。据推测，ATP和乙酰胆碱激活的Ca2+信号在空间上是分开的，分别在主要定位有SK通道和IR通道的质膜区域产生。
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