Distribution of HERV-LTR elements in HLA-DQB1 alleles: comments on the article by Bieda et al.

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作者信息

Pascual M, Koeleman B P, Eerligh P, Roep B O, Martin J

出版信息

Diabetologia. 2003 Jun;46(6):869-70; author reply 870-1. doi: 10.1007/s00125-003-1113-9. Epub 2003 Jun 11.

DOI:10.1007/s00125-003-1113-9

PMID:12802499

Abstract

摘要

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Distribution of HERV-LTR elements in HLA-DQB1 alleles: comments on the article by Bieda et al.

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A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I diabetes susceptibility on high risk DQ haplotypes.与HLA DQB1基因相邻的逆转录病毒长末端重复序列（DQ-LTR13）改变了高风险DQ单倍型上的I型糖尿病易感性。

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Intronic sequence motifs of HLA-DQB1 are shared between humans, apes and Old World monkeys, but a retroviral LTR element (DQLTR3) is human specific.人类、猿类和旧世界猴的HLA - DQB1内含子序列基序是共享的，但一种逆转录病毒LTR元件（DQLTR3）是人类特有的。

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本文引用的文献

Diabetologia. 2002 Mar;45(3):443-7. doi: 10.1007/s00125-001-0753-x.

Immunogenetics. 2001 Mar;53(2):114-8. doi: 10.1007/s002510100307.

The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry.

J Clin Endocrinol Metab. 1999 Apr;84(4):1404-8. doi: 10.1210/jcem.84.4.5638.

An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis.

Hum Immunol. 1999 Jan;60(1):63-8. doi: 10.1016/s0198-8859(98)00095-0.

Large-scale sequence comparisons reveal unusually high levels of variation in the HLA-DQB1 locus in the class II region of the human MHC.大规模序列比较显示，人类主要组织相容性复合体（MHC）Ⅱ类区域的HLA-DQB1基因座存在异常高水平的变异。

J Mol Biol. 1998 Sep 11;282(1):71-97. doi: 10.1006/jmbi.1998.2018.

Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.人类主要组织相容性复合体（MHC）II类区域内非编码序列的进化动力学

J Mol Biol. 1996 Jan 12;255(1):1-13. doi: 10.1006/jmbi.1996.0001.

Endogenous retroviral long terminal repeats within the HLA-DQ locus.HLA-DQ基因座内的内源性逆转录病毒长末端重复序列。

Proc Natl Acad Sci U S A. 1990 Jul;87(13):4927-31. doi: 10.1073/pnas.87.13.4927.

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