Kim Byung Hak, Chung Eun Yong, Min Bo-Kyung, Lee Seung Ho, Kim Mi-Kyeong, Min Kyung Rak, Kim Youngsoo
Planta Med. 2003 May;69(5):474-6. doi: 10.1055/s-2003-39712.
Soy is a main source of isoflavonoids which are of high dietary intake for the oriental population. In this study, the anti-inflammatory action of sophoricoside, an isoflavone glycoside isolated from immature fruits of Sophora japonica L. (Leguminosae), has been demonstrated. When administered orally at > 100 mg/kg or injected intravenously at > 10 mg/kg, sophoricoside showed significant reduction of carrageenin-induced paw edema in mice. Sophoricoside has been identified as a selective inhibitor of cyclooxygenase (COX)-2 activity with an IC50 value of 3.3 microM.
大豆是异黄酮的主要来源，而东方人群的异黄酮膳食摄入量较高。在本研究中，已证实了从豆科植物槐（Sophora japonica L.）未成熟果实中分离出的异黄酮糖苷槐角苷的抗炎作用。当以大于100 mg/kg的剂量口服或大于10 mg/kg的剂量静脉注射时，槐角苷可使角叉菜胶诱导的小鼠爪肿胀显著减轻。槐角苷已被鉴定为环氧合酶（COX）-2活性的选择性抑制剂，IC50值为3.3 microM。
