Perry Alison R, Shaw Margaret A, Cotton Susan
School of Human Communication Sciences, Faculty of Health Sciences, La Trobe University and Department of Biostatistics, La Trobe University, Victoria, Australia.
J Laryngol Otol. 2003 May;117(5):368-81. doi: 10.1258/002221503321626410.
We have earlier reported establishing a computerized database to audit functional outcomes in patients who underwent head and neck cancer treatment in Victoria, Australia and attended speech pathology services from April 1997-April 1999. This paper presents the statistical analyses and results from this study. Speech pathologists collected, prospectively, functional outcome data on 293 patients who underwent head and neck cancer treatment, and sent these for analysis to La Trobe University. Clinician and patient assessments of outcomes: speech, swallowing, activity, pain, employment, health, QOL status were made. Initial data on 293 patients were collected and data on mortality and morbidity were compiled at three, six and 12 months post-treatment. Within twelve months, 74 patients had died. Three, six and/or 12-month follow-up data was available on 219 patients, with both clinician and patient assessments of status completed. The status forms are presented as appendices to this paper. Complete status forms on 179 patients at 12 months were obtained. This clinical audit of functional outcomes represents the first study of this kind, collecting data from speech pathologists and patients in a multi-centre study of patients with head and neck cancer. We present data to demonstrate optimal recovery of function at six months, such that this may represent a good reference point for reporting and comparison of functional outcomes.
我们之前曾报道过建立一个计算机化数据库,以审核在澳大利亚维多利亚州接受头颈癌治疗并于1997年4月至1999年4月期间接受言语病理学服务的患者的功能结局。本文介绍了该研究的统计分析和结果。言语病理学家前瞻性地收集了293名头颈癌治疗患者的功能结局数据,并将这些数据发送至拉筹伯大学进行分析。对结局进行了临床医生和患者评估:包括言语、吞咽、活动、疼痛、就业、健康、生活质量状况。收集了293名患者的初始数据,并在治疗后3个月、6个月和12个月编制了死亡率和发病率数据。在12个月内,74名患者死亡。219名患者有3个月、6个月和/或12个月的随访数据,同时完成了临床医生和患者对病情的评估。状态表格作为本文的附录呈现。获得了179名患者在12个月时的完整状态表格。这种对功能结局的临床审核代表了此类的第一项研究,在一项针对头颈癌患者的多中心研究中收集了言语病理学家和患者的数据。我们展示数据以证明在6个月时功能的最佳恢复情况,因此这可能是报告和比较功能结局的一个良好参考点。