六亚甲基二异氰酸酯引起的超敏性肺炎

Hypersensitivity pneumonitis induced by hexamethylene diisocyanate.

作者信息

Usui Y, Aida H, Kimula Y, Miura H, Takayama S, Nakayama M

机构信息

Department of Internal Medicine, Yokosuka Kyosai Hospital, Japan.

出版信息

Intern Med. 1992 Jul;31(7):912-6. doi: 10.2169/internalmedicine.31.912.

DOI:10.2169/internalmedicine.31.912

PMID:1280491

Abstract

A case of hypersensitivity pneumonitis (HP) induced by hexamethylene diisocyanate (HDI) is described. Serial determinations of the lymphocyte surface phenotypes by two-color assay revealed the following: 1) increased activated cytotoxic T lymphocytes in the bronchoalveolar lavage fluid (BALF), and 2) increased percentage and absolute number of non-major histocompatibility complex (MHC)-restricted natural killer (NK) cells in the peripheral blood (PB) during the recovery phase of the disease. These findings were considered to be related to the activity of the disease.

摘要

本文描述了一例由六亚甲基二异氰酸酯（HDI）诱发的超敏性肺炎（HP）病例。通过双色分析法对淋巴细胞表面表型进行连续测定，结果如下：1）支气管肺泡灌洗液（BALF）中活化的细胞毒性T淋巴细胞增加；2）在疾病恢复期，外周血（PB）中非主要组织相容性复合体（MHC）限制性自然杀伤（NK）细胞的百分比和绝对数量增加。这些发现被认为与疾病活动有关。