蛋白质组的进化。

Evolution of the protein repertoire.

作者信息

Chothia Cyrus, Gough Julian, Vogel Christine, Teichmann Sarah A

机构信息

Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

出版信息

Science. 2003 Jun 13;300(5626):1701-3. doi: 10.1126/science.1085371.

DOI:10.1126/science.1085371

PMID:12805536

Abstract

Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.

摘要

大多数蛋白质是通过基因复制、重组和分化形成的。已知结构的蛋白质可以与约50%的基因组序列相匹配，这些数据提供了定量描述，并能就这些过程的起源提出假设。