果蝇转录组的性别依赖性基因表达与进化

Sex-dependent gene expression and evolution of the Drosophila transcriptome.

作者信息

Ranz José M, Castillo-Davis Cristian I, Meiklejohn Colin D, Hartl Daniel L

机构信息

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

Science. 2003 Jun 13;300(5626):1742-5. doi: 10.1126/science.1085881.

DOI:10.1126/science.1085881

PMID:12805547

Abstract

Comparison of the gene-expression profiles between adults of Drosophila melanogaster and Drosophila simulans has uncovered the evolution of genes that exhibit sex-dependent regulation. Approximately half the genes showed differences in expression between the species, and among these, approximately 83% involved a gain, loss, increase, decrease, or reversal of sex-biased expression. Most of the interspecific differences in messenger RNA abundance affect male-biased genes. Genes that differ in expression between the species showed functional clustering only if they were sex-biased. Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome.

摘要

黑腹果蝇和拟果蝇成虫之间基因表达谱的比较揭示了表现出性别依赖性调控的基因的进化情况。大约一半的基因在这两个物种之间表现出表达差异，其中约83%涉及性别偏向性表达的获得、丧失、增加、减少或反转。信使核糖核酸丰度的大多数种间差异影响雄性偏向性基因。只有在基因具有性别偏向性时，物种间表达不同的基因才会出现功能聚类。我们的结果表明，性别依赖性选择可能推动果蝇转录组中许多进化最快的基因的表达发生变化。