Axelrod Jeffrey D, McNeill Helen
Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305-5324, USA.
ScientificWorldJournal. 2002 Feb 15;2:434-54. doi: 10.1100/tsw.2002.105.
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.
上皮细胞和其他细胞群获得了与其顶-基轴正交的极性，称为平面细胞极性（PCP）。这些细胞极化的过程需要一条以卷曲蛋白作为受体的信号通路。响应细胞感知来自其环境的线索，这些线索提供方向信息，然后它们将此信息转化为细胞不对称性。关于PCP的大部分已知信息来自对果蝇的研究。我们回顾了关于细胞如何将未知信号转化为不对称细胞骨架重组的已知信息。然后我们讨论脊椎动物的汇聚延伸和耳蜗毛细胞发育过程可能与果蝇PCP信号传导有何关系。
