从鼻尖往后。

Back from the tip of the nose.

作者信息

Cossu G

机构信息

Stem Cell Research Institute, H.S. Raffaele Milan and Dept. of Histology and Medical Embryology, II Medical School, University of Rome, La Sapienza, Italy.

出版信息

ScientificWorldJournal. 2001 Jun 5;1:225-6. doi: 10.1100/tsw.2001.26.

DOI:10.1100/tsw.2001.26

PMID:12806091

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6083894/

Abstract

About 130 years ago, Giulio Bizozzero, then in Pavia, made a seminal observation [1]. He divided the tissues of the vertebrate body into three categories: those that divide constantly (labile), such as blood and skin, those that never divide, such as striated muscle and brain (perennial), and those that normally do not divide but can do so if injured (stable). As a consequence, diseases that perturb cell division, such as cancer, affect labile tissues, while degenerative diseases affect perennial tissues where repair is inefficient. Epithelia and blood possess a reservoir of cells that divide and maintain a progenitor pool throughout life (the stem cells) whereas striated muscle and brain were supposed not to contain stem cells. Furthermore, stem cells were supposed to generate only the cells of the tissue where they belong.

摘要

大约130年前，当时在帕维亚的朱利奥·比佐泽罗做出了一项具有开创性的观察[1]。他将脊椎动物身体的组织分为三类：持续分裂的组织（不稳定组织），如血液和皮肤；从不分裂的组织（永久性组织），如横纹肌和大脑；通常不分裂但在受伤时可以分裂的组织（稳定组织）。因此，扰乱细胞分裂的疾病，如癌症，会影响不稳定组织，而退行性疾病则会影响修复效率低下的永久性组织。上皮组织和血液拥有一群终生分裂并维持祖细胞库的细胞（干细胞），而横纹肌和大脑则被认为不含干细胞。此外，干细胞应该只产生它们所属组织的细胞。