Yabuki Akira, Matsumoto Mitsuharu, Nishinakagawa Hayao, Suzuki Syusaku
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University, 21-24 Korimoto 1, Kagoshima-shi, Kagoshima 890-0065, Japan.
Exp Anim. 2003 Apr;52(2):159-63. doi: 10.1538/expanim.52.159.
The DBA/2Cr mouse is characterized by the presence of giant lysosomes located in the proximal convoluted tubules of males and proximal straight tubules of females. However, it remains unclear whether these giant lysosomes in the proximal tubules are characteristic of DBA/2Cr specifically, or are common to other DBA/2 substrains and DBA/1. The present study investigated the morphology of kidneys from DBA/2CrSlc, DBA/2JJcl, DBA/2NCrj and DBA/1JNCrj mice of both sexes. Giant lysosomes in the renal proximal tubules were found to represent common morphological characteristic of both DBA/2 and DBA/1JN.
DBA/2Cr小鼠的特征是在雄性的近端曲管和雌性的近端直管中存在巨大溶酶体。然而，目前尚不清楚近端小管中的这些巨大溶酶体是DBA/2Cr特有的特征，还是其他DBA/2亚系和DBA/1所共有的。本研究调查了DBA/2CrSlc、DBA/2JJcl、DBA/2NCrj和DBA/1JNCrj两性小鼠肾脏的形态。发现肾近端小管中的巨大溶酶体是DBA/2和DBA/1JN共有的形态特征。
