Tsuji Yasushi, Sagawa Tamotsu, Takayanagi Norihiro, Hirayama Yasuo, Sakamaki Sumio
Department of Internal Medicine, Higashi Sapporo Hospital.
Nihon Rinsho. 2003 Jun;61(6):966-72.
Digestive complications are frequent dose-limiting side-effect of chemotherapy. Diarrhea and constipation can affect quality of life and alter optimum treatment efficacy. The incidence and the severity of these toxicities have to be systematically evaluated in order to provide specific curative and preventive treatments. This review shows the recommended guidelines for the treatment of chemotherapy-induced diarrhea and the recent therapeutic approaches. The management of gastrointestinal graft-versus-host disease and neutropenic enterocolitis is also described. Prevention and early recognition is critical to avoid sever life-threatening complications and improve quality of life.
消化并发症是化疗常见的剂量限制性副作用。腹泻和便秘会影响生活质量并改变最佳治疗效果。必须系统评估这些毒性的发生率和严重程度,以便提供具体的治疗和预防措施。本综述展示了化疗引起的腹泻的推荐治疗指南以及最新的治疗方法。还描述了胃肠道移植物抗宿主病和中性粒细胞减少性小肠结肠炎的管理。预防和早期识别对于避免严重的危及生命的并发症和提高生活质量至关重要。